Investigative Ophthalmology & Visual Science Vol. 56

Feasibility Study in Normal Children of a Liquid Crystal Spectacle Filter (LCSF) for Potential Treatment of Amblyopia

Purpose: To evaluate a new LCSF device applied to commercial eyeware for both comfort and the potential to reduce visual acuity
Methods: AlphaMicron Inc. Kent, Ohio, has developed a liquid crystal system designed specifically for eyewear which uses a polymer liquid crystal mixture consisting of “guest” monomers in a liquid crystal “host”. This mixture is sandwiched between two curved flexible plastic substrates coated with transparent electrodes. By applying voltage to the substrates, the electro-optic response of the liquid crystal mixture is used to control the opacity of the device. The voltage is applied manually with a touch of a button or automatically through a sensor, providing instantaneous control over transmission. 20 normal children ages 7-10 were testing while wearing the LCSF. The amount of light transmission measure as a voltage was correlated to monocular and binocular visual acuity degradation using the PEDIG acuity testing paradigm.
Results: The LCSF is successfully able to depress visual acuity in a linear fashion by changing the “haze” or light transmission function in a stepwise fashion from 20/20 to light perception.
Conclusions: The LCSF filter may provide multiple benefits in the treatment of, including; ease of application to commercially available eyeware, cosmetic appeal, comfort, versatility in occlusion dosage and the potential to improve adherence.